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KMID : 0363220090470101120
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Korean Journal of Dermatology
2009 Volume.47 No. 10 p.1120 ~ p.1126
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Treatment of External Ear Keloids with the Application of Imiquimod 5% Cream after a Parallel Shave Excision
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Kim Tae-Yoon
Yoon Moon-Soo
Kim Dong-Hyun
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Abstract
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Background: Keloids are slow-growing neoplasms that are characterized by a benign proliferation of fibroblasts in the setting of an altered cytokine profile. The traditional treatment modalities for external ear keloids are often associated with high recurrence rates.
Objective: The purpose of this study is to investigate the efficacy and safety of applying imiquimod 5% cream after parallel shave excision for the treatment of external ear keloids.
Methods: Twenty-two keloids from 19 patients were treated with parallel shave excision and this was followed by daily application of imiquimod 5% cream for 8 weeks. The patients were examined every 2 weeks for up to 24 weeks for recurrence of the keloids and any side effects.
Results: At the end of the 24-week follow-up period, 15 keloids (68.2%) remained recurrence free. Seven of these have remained recurrence free for a period ranging from 29 to 131 weeks. The common local side effects were burning (59.1%), pain (36.4%) and itching (27.3%), but there were no severe systemic side effects. Most of the patients experienced erythema (90.9%) and crust (77.3%) at the application sites and 3 patients (13.6%) reported transient hyperpigmentation on the surrounding areas.
Conclusion: The application of imiquimod 5% cream after parallel shave excision can be an effective treatment modality for external ear keloids with mild and acceptable side effects.
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KEYWORD
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Imiquimod, Keloid, Shave excision
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